taxus brevifolia การใช้

• Paclitaxel was identified from Pacific yew tree " Taxus brevifolia ".
• This was a drug that had been obtained from the yew plant " Taxus brevifolia ".
• The first drug of their class, paclitaxel, was originally extracted from the Pacific Yew tree, " Taxus brevifolia ".
• Paclitaxel is based on the terpenoid natural product taxol, which is isolated from " Taxus brevifolia " ( the pacific yew tree ).
• "Taxus brevifolia " var . " reptaneta " has also been proposed to be elevated to subspecies status without justification or explanation.
• This endophyte is likely the cause of the decline of Florida torreya ( " Torreya taxifolia " ), an endangered species that is related to the taxol-producing Taxus brevifolia.
• Typical " Taxus brevifolia ", like most species in the genus, usually produces a single ovule on a complex scaly shoot, composed of a primary shoot and a secondary short shoot.
• These scientists isolated the natural product from the bark of the Pacific yew tree, " Taxus brevifolia ", determined its structure and named it " taxol ", and arranged for its first biological testing.
• However, the roots of the mandrake plant also contain large quantities of the alkaloid anticancer drug, taxol, isolated from the bark of the Pacific yew, " Taxus brevifolia ", in the early 1960s.
• "' 10-Deacetylbaccatins "'are a series of closely related natural organic compounds isolated from the Pacific yew tree ( " Taxus brevifolia " ) and related species . 10-Deacetylbaccatin III is a precursor to the anti-cancer drug docetaxel ( Taxotere ).
• The Pacific yew ( " Taxus brevifolia " ), native to the Pacific Northwest of North America, and the Canada yew ( " Taxus canadensis " ) are the sources of paclitaxel or Taxol, a breast and lung cancer treatment and, more recently, in the production of the Taxus drug eluting stent by Boston Scientific.
• However, " Taxus brevifolia " var . " polychaeta " differs from var . " brevifolia " in producing a relatively longer primary shoot The epithet, " polychaeta ", is in reference to the primary shoot resembling a polychaete worm; hence, its common name  worm cone yew .  Variety " polychaeta " appears to be relatively rare.
• While the " political climate surrounding taxol and " Taxus brevifolia " in the early 1990s & helped bolster [ a ] link between total synthesis and the [ taxol ] supply problem ", and though total synthesis activities were a requisite to explore the structure-activity relationships of taxol via generation of analogs for testing, the total synthesis efforts were never seen " as a serious commercial route " to provide significant quantities of the natural product for medical testing or therapeutic use.
• "Taxus canadensis " is also being harvested in northern Ontario, Qu閎ec and Atlantic Canada as the plant is a source of the class of poisonous chemicals known as taxanes, which have been a focus for cancer research . " T . canadensis " is much more abundant than the near-threatened " Taxus brevifolia " ( Pacific Yew ), and the " greens " ( new growth ) can be harvested sustainably every five years, instead of stripping the bark and killing the plant.